PRODUCT MONOGRAPH. PR. Cathflo. ® alteplase, recombinant . cell line into which the cDNA for alteplase has been genetically inserted. Read all of this leaflet carefully before you What Actilyse Cathflo is and what it is used for. 2. Contents of the pack and other information. 1. Drug monographs for CATHFLO ACTIVASE provide an overview of the drug Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the .

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View videos and instructions for the recommended dosing and administration of Cathflo. Hypersensitivity, including urticaria, angioedema and anaphylaxis, has been reported in association with use of Cathflo Activase. A solution of 0. Packaage are no adequate and well-controlled studies in pregnant women.

The information contained in this section of the site is intended for U. In clinical trials, the most serious adverse events reported after treatment were sepsis, gastrointestinal bleeding, and catjflo thrombosis.

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In elderly patients, the benefits of therapy should be carefully weighed against the risk of increased adverse events, including bleeding.

Remove the appropriate indication-specific volume from the reconstituted vial using a syringe and needle. There inset no efficacy or safety information on dosing in excess of 2 mg per dose for this indication.

Various doses and administration times have been studied; the lowest effective dose has not been determined.

Children weighing 10 to 29 kg. Safety and efficacy have not been established for systemic thrombolysis; various regimens have been used.


Cathflo Activase (alteplase) dose, indications, adverse effects, interactions from

Major Coadministration of edoxaban and thrombolytic agents should be avoided due to an increased risk of bleeding during concurrent use. Rates of serious adverse reactions and catheter function restoration were similar between pediatric patients and those seen in adults.

There czthflo an increased risk of intracranial hemorrhage in patients with severe neurological deficit e. As with all catheterization procedures, care should be used to maintain aseptic technique. Limited studies in patients with myocardial infarction and patients with thromboembolic disease indicate that the terminal half-life of alteplase is approximately 45 and 30 minutes, respectively.

Agree with leaving cath flow for minutes if doesn’t clear out the first time.

Single-Use Vial Lytic Thrombolytic – Cathflo® Activase® (alteplase)

Moderate Concurrent administration of thrombolytic agents and salicylates may further increase the serious risk of bleeding. Moderate Agents that may effect hemostasis including sulfinpyrazone, can increase the likelihood of hemorrhage if administered during or immediately before therapy with thrombolytic agents.

Wible and his cxthflo author team provide carefully updated information in a concise, bulleted format, keeping you current with recent advances in interventional radiology. The interaction of Cathflo Activase with other drugs has not been formally studied.

Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed. Weight-based dosing of 0.

Patients should be instructed to monitor for signs and symptoms of bleeding while taking an SNRI with medications which impair platelet function and to promptly report any bleeding ctahflo to the practitioner. Choline Salicylate; Magnesium Salicylate: Severe Based on the pharmacology of warfarin, other thrombolytic agents could cause additive risk of bleeding when given concurrently with warfarin. Has anyone done this?


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The risks of alteplase therapy may be increased in patients with significant hepatic impairment and should be weighed against the anticipated benefits. In exploratory, multivariate analyses, age more than 77 years was among baseline vathflo associated with an increased risk for intracranial hemorrhage. Major During and after therapy, avoid the concomitant use of Yttrium Y ibrutumomab tiuxetan with drugs that interfere with coagulation such as thrombolytic agents; the risk of bleeding may be increased.

Intracatheter instillation dosage Cathflo Alteplase. Unlike streptokinase or urokinase, most of the activity of alteplase is dependent on the presence of fibrin. Dwell times of 0. Alteplase may increase the insett of thromboembolic events in these conditions where there is a high likelihood of left heart thrombus, such as patients with mitral stenosis or atrial fibrillation.

I hope this was helpful to you. Other clinical data exist that describe spontaneous subdural hematomas associated with chronic Ginkgo biloba ingestion. The patients described were 12, 13, and 16 years old. Does vathflo allow the Cathflo to dwell for up to the full minutes?

If an arterial puncture is necessary, use an upper extremity vessel accessible to manual compression, inserrt pressure for at least 30 minutes, and monitor the puncture site closely for evidence of bleeding.